Genomic Characterization of <i>Klebsiella pneumoniae</i> Causing Invasive Disease in South African Infants: Observational Studies Between 2018 and 2023.

ABSTRACT:

Background

Klebsiella pneumoniae (KPn) is a leading cause of invasive bacterial disease in African children, albeit with a scarcity of genotypic characterization.

Methods

We sequenced invasive KPn isolates from infants ≤90 days, collected through observational hospital surveillance (n = 226) between March 4, 2019 and February 27, 2021, and between May 13, 2022 and October 31, 2023, and postmortem sampling (n = 111) between February 15, 2018 and April 18, 2023. Postmortem Kpn isolates were attributed in the causal pathway to death by the determination of the cause of death panel, which consists of local experts.

Results

Three hundred and thirty-seven isolates (226 identified during hospital surveillance and 111 from postmortem sampling) were included in the fina

SUBMITTER: Olwagen CP 

PROVIDER: S-EPMC12828431 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature