Tackling the Reactivity of Propadiene: Palladium Metallaphotoredox Dual Catalyzed Multi-Component Allylation and Dienylation of Styrenes.

ABSTRACT: Catalytic transformations of feedstock chemicals into value-added products are a long-standing challenge. A side product of the steam-cracking process - propadiene - which is formed in 2.5 x 10⁵ t/y - regardless of its potentially rich chemistry - is usually wasted by burning it. To make more economical and sustainable use of valuable carbon atoms from feeds stocks, herein we report a palladium metallaphotoredox dual catalyzed multi-component allylation and dienylation of styrene derivatives with propadiene as either an allylation or a dienylation reagent. The chemoselectivity for both directions are higher than 20:1 and pronounced functional group tolerance has been elucidated in both cases. Gram scale synthesis and orthogonal reactivities towards thermo allylation demonstrate

SUBMITTER: Yang YF 

PROVIDER: S-EPMC12828483 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature