Pancreatic cancer risk and survival in patients with Lynch syndrome: a nationwide Dutch cohort study.

ABSTRACT:

Background

Individuals with Lynch syndrome (LS) are advised to undergo pancreatic ductal adenocarcinoma (PDAC) surveillance if their lifetime risk is ≥5%, however, evidence is limited. This study quantifies lifetime risk and survival of three cancers relevant to PDAC surveillance, including PDAC, ampullary carcinoma (AC) and distal cholangiocarcinoma (dCC), to evaluate whether surveillance is justified.

Methods

This retrospective nationwide Dutch cohort study included individuals with LS pathogenic variants (PVs) in MLH1, MSH2, MSH6, PMS2 or EpCAM (identified between 1985 and 2024) and compared them to sporadic cases from the general population (diagnosed between 2000 and 2022). Cumulative incidence (CI) of PDAC, AC and dCC was estimated us

SUBMITTER: Bogdanski AM 

PROVIDER: S-EPMC12828513 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature