Risk for coronary artery disease among individuals with normal low-density lipoprotein cholesterol (LDL-C) levels.

ABSTRACT:

Background

Low-density lipoprotein cholesterol (LDL-C) levels <100 mg/dL are generally considered normal. We tested the controversial hypothesis that a subset of individuals with 'normal' LDL-C levels may have a non-negligible risk of coronary artery disease (CAD) due to inherited factors, including monogenic variants and polygenic risk scores (PGS).

Methods

A retrospective analysis of a prospective cohort from the Genomic Health Initiative at Endeavor Health, including 7880 participants without a prior diagnosis of CAD and not on statins at recruitment. Participants were stratified by baseline LDL-C levels and followed for incident CAD. The association of CAD risk with carrier status for pathogenic/likely pathogenic (P/LP) variants in LDLR, APOB, and PCSK9<

SUBMITTER: Shi Z 

PROVIDER: S-EPMC12828546 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature