Chronic stress antagonizes formation of stress granules.

ABSTRACT: Stress granules (SGs) are cytoplasmic ribonucleoprotein condensates formed in response to stress-induced inhibition of mRNA translation and polysome disassembly. Despite the broad interest in SG assembly and disassembly in response to acute stress, SG dynamics under chronic stress has not been extensively investigated. We show that cells pre-conditioned with low-dose chronic (24 h exposure) stresses of various natures fail to assemble SGs in response to acute stress. While protein synthesis is drastically decreased by acute stress in pre-conditioned cells, polysome profiling analysis reveals the partial preservation of polysomes. Mechanistically, chronic stress slows down the rate of mRNA translation at the elongation phase, and triggers phosphorylation of translation elongation factor eEF

SUBMITTER: Adachi Y 

PROVIDER: S-EPMC12828549 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature