Non-antibiotic lipid complex-in-thermogel strikes twice: multimodal photosensitive antibacterial meets immunomodulation-boosted healing for periodontitis treatment.

ABSTRACT: Periodontitis is a chronic oral disease characterized by gingival inflammation and periodontium injury due to repeated pathogenic bacteria infection and overactive inflammatory response. Multidrug resistance and the quick loss of antibiotics in the oral cavity create challenges for treatment. Therefore, a novel non-antibiotic-dependent pharmaceutical strategy is crucial for clinical treatment of periodontitis. In this study, we developed a lipid complex-in-thermogel delivery system (IQ-ML@Gel) co-loading the photosensitizer of indocyanine green and the immunomodulator of quercetin. IQ-ML@Gel could stably adhere in the periodontal pocket through liquid-solid transformation in situ. In vitro studies confirmed the efficient elimination of Porphyromonas gingivalis and F

SUBMITTER: Li J 

PROVIDER: S-EPMC12828598 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature