Exploring the therapeutic potential of baicalin against MCF-7 breast cancer cells: biochemical, <i>in vitro</i>, and computational perspectives.

ABSTRACT:

Background

Baicalin (BA), a flavonoid extracted from the dried roots of Scutellaria baicalensis, is well known in traditional Chinese medicine (TCM) for its anti-apoptotic, anti-inflammatory, and antioxidant activities. However, its therapeutic potential in breast cancer needs to be evaluated systematically.

Methods

In this study, BA was isolated by probe sonication, bath-assisted sonication, and maceration. Chemical and structural characterisation was done by UV-VIS, Fourier-transform infrared spectroscopy (FT-IR), high-performance thin-layer chromatography (HPTLC), high-performance liquid chromatography (HPLC), liquid chromatography-mass spectrometry (LC-MS), X-ray diffraction (XRD), and nuclear magnetic resonance (NMR), while morphological and physicochemical attri

SUBMITTER: Ali A 

PROVIDER: S-EPMC12828673 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature