<i>In Vivo</i> Evaluation of a Self-Excitatory Near-Infrared ImmunoSCIFI Probe.

ABSTRACT: Secondary Cerenkov-induced fluorescence imaging (SCIFI) utilizes blue-weighted Cerenkov luminescence from radioactive decay to excite proximal fluorophores that emit near-infrared light with optimal penetrance through biological tissues and offers potential utility in clinical imaging applications, including guidance of surgical resection. Recently, we developed a self-excitatory immunoSCIFI probe based on an antibody modified with the Cerenkov luminescence generating radioisotope zirconium-89 and a near-infrared boron-dipyrromethene dye (BOD665) and observed an immunoSCIFI signal in in vitro cell-based experiments. In this study, we have evaluated the in vivo application of immunoSCIFI using a clinically relevant orthotopic mouse model of dedifferentiated chondrosarcoma as a

SUBMITTER: Gristwood K 

PROVIDER: S-EPMC12828711 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature