Zn-Quer Nanozymes Reprogram the Malignant Phenotypic Transformation of Gastric Cancer Cells via Cascade Reactive Oxygen Species Coordination.

ABSTRACT: Gastric cancer (GC) remains one of the leading causes of cancer-related mortality worldwide, presenting significant therapeutic challenges due to its late-stage diagnosis and high metastatic potential. Imbalance in reactive oxygen species (ROS) homeostasis is crucial for the onset, development, and malignant transformation of GC. To address the demand for innovative therapeutic approaches, this study introduces a novel nanocoordination polymer, Zn-Quer nanozymes (NZs), synthesized from quercetin (Quer) and zinc ions. These nanoparticles utilize quercetin's anti-inflammatory and antioxidant properties, improving its bioavailability and therapeutic effectiveness via a nanoparticle delivery system. Zn-Quer NZs were synthesized via coordination chemistry and characterized by using TEM, XRD, an

SUBMITTER: Jiang H 

PROVIDER: S-EPMC12828714 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature