Familial clusters and clinical features, complications, and outcomes in 1000 patients with Waldenstrom macroglobulinemia.

ABSTRACT:

Abstract

Approximately 20% of patients with Waldenström macroglobulinemia (WM) report family history (FH) of hematologic malignancies. However, the impact of FH on patient outcomes remains unclear. We included 1000 patients with WM to determine the relationship between FH, characteristics, complications, and treatment outcomes. Data collected included clinical features at diagnosis, complications (Bing-Neel syndrome [BNS], aggressive transformation, AL [light chain] amyloidosis, and neuropathy), FH cluster (WM [WM-FH], other B-cell FH [B-FH], non-B-cell FH [NON-B-FH], and sporadic [NO-FH]), and treatment outcomes. Logistic regression models were fitted to estimate the odds of complications. Time-to-event outcomes were assessed using the Kaplan-Meier method, and differences between

SUBMITTER: Ramirez-Gamero A 

PROVIDER: S-EPMC12828760 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature