Neuroinflammation demonstrated by ¹¹C-ER176 PET with amyloid and tau pathology.

ABSTRACT:

Introduction

Understanding neuroinflammation across the Alzheimer's disease (AD) spectrum is essential to elucidate disease mechanisms and individualize therapy.

Methods

Human microglial translocator protein (TSPO) expression under inflammatory stimuli was assessed by immunoblot experiments. Ninety-six participants were enrolled across four groups: cognitively unimpaired amyloid (CU A) + and -, mild cognitive impaired (MCI) A+, and Alzheimer's disease dementia (ADD) A+. Neuroinflammation using ¹¹C-ER176 TSPO positron emission tomography (PET) was compared to amyloid and tau PET. Correlations between neuroinflammation, amyloid, and tau pathology were examined across disease stages.

Results

TSPO was upregulated in human microglia under AD-like inflammatory co

SUBMITTER: Kandimalla M 

PROVIDER: S-EPMC12828788 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature