Progression of stenosis severity and aortopathy in adult patients with congenital aortic stenosis.

ABSTRACT:

Background

Congenital aortic stenosis (AS) is a heterogeneous disease. However, repeated data describing disease progression is limited, especially in adults. Therefore, the objective of this study is to investigate progression of peak velocity and aortic dimensions in adult congenital AS patients, identifying markers for fast progression.

Methods

Adult patients (aged 18-55 years) with a native aortic valve and at least mild AS at baseline registered in the Dutch CONCOR registry between 2001 and 2019 from all six tertiary expert centers for congenital heart disease were included. Patients with severe aortic regurgitation at baseline or no available echocardiograms during follow-up were excluded. Data on ascending aortic dimensions and peak velocity changes over time were ana

SUBMITTER: Keuning ZA 

PROVIDER: S-EPMC12828805 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature