Targeting macrophages prevents alloantibody-mediated platelet clearance in a murine model of transfusion refractoriness.

ABSTRACT:

Abstract

HLA class I-immunized patients can experience a serious complication known as platelet transfusion refractoriness (PTR). This issue becomes especially relevant in onco-hematology departments where platelet transfusions are at the heart of patient care. Although transfusion failure is evidenced by a rapid elimination of allogeneic platelets from the recipient's bloodstream, the mechanisms behind it remain poorly characterized. The aim of this study was to better define these mechanisms to improve therapy for PTR. Using a murine model of major histocompatibility complex class I incompatibility to mimic PTR, we first established that antibodies, but not natural killer or CD8 cells, mediated platelet clearance. However, blocking Fcγ receptors with intravenous immunoglobulin or

SUBMITTER: Rojas-Jimenez G 

PROVIDER: S-EPMC12828813 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature