Utility of placental growth factor for preeclampsia prediction in pregnancies complicated by sickle cell disease.

ABSTRACT:

Abstract

Outside of pregnancy, placental growth factor (PlGF), is produced by erythroid cells in typically undetectable levels. In pregnancy, PlGF is strongly expressed by the trophoblast layer covering the placental villi. PlGF levels rise progressively due to placental growth, peak at 28 to 30 weeks gestation, and then slowly decline toward term. Low PlGF has emerged as a powerful diagnostic test for preterm preeclampsia. However, its interpretation in context of sickle cell disease (SCD) is potentially confounded by upregulation of cellular PlGF expression in nonpregnant individuals with SCD, and higher third trimester circulating PlGF levels documented in healthy Black compared with White individuals. Primary objectives were to determine the distribution of PlGF at midtrimester

SUBMITTER: Vlachodimitropoulou E 

PROVIDER: S-EPMC12828821 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature