Dysregulated metabolism of ceramides and glycosphingolipids in Parkinson's disease.

ABSTRACT: Alterations in sphingolipid metabolism have been implicated in the pathogenesis of Parkinson's disease (PD), yet findings regarding peripheral sphingolipid changes remain inconsistent. This study aimed to elucidate the metabolic profiles of plasma ceramides and glycosphingolipids (GSLs) in patients with PD. We recruited 250 patients with PD and 250 age- and sex-matched neurologically healthy controls. Plasma ceramide and GSL species were quantified using liquid chromatography‒tandem mass spectrometry, complemented by a meta-analysis of the gene expression levels of relevant enzymes in the substantia nigra obtained from Gene Expression Omnibus. A total of 119 sphingolipids were analyzed. Significant differences in plasma sphingolipid species were observed, including increased GSLs and decre

SUBMITTER: Peng YF 

PROVIDER: S-EPMC12828830 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature