MITF, TFEB, and TFE3 drive distinct adaptive gene expression programs and immune infiltration in melanoma.

ABSTRACT: Cells can contain multiple related transcription factors targeting the same sequences, leading to potential regulatory cooperativity, redundancy, competition, or temporally regulated factor exchange. Yet, the differential biological functions of co-targeting transcription factors are poorly understood. In melanoma, three highly related transcription factors are co-expressed: the mammalian target of rapamycin complex 1 (mTORC1)-regulated TFEB and TFE3 (both key effectors of a wide range of metabolic and microenvironmental cues assumed to perform similar functions) and the microphthalmia-associated transcription factor (MITF), which controls melanoma phenotypic identity. Here, we reveal the functional specialization of MITF, TFE3, and TFEB and their impact on melanoma progression. Notably, a

SUBMITTER: Dias D 

PROVIDER: S-EPMC12828906 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature