Comparing low volume versus intermediate volume bowel preparation and their impact on work and tolerability: an open-label, noninferiority randomized controlled trial.

ABSTRACT: Bowel preparation is essential for colonoscopy but may deter patients. Although low volume laxatives are better tolerated, their impact on patient-reported outcomes remains unclear. We compared low and intermediate volume bowel preparation and assessed their impact on tolerability, health-related quality of life (HRQoL), and work.We conducted an open-label, noninferiority randomized trial in four Dutch hospitals. Patients were randomized to 2 L polyethylene glycol with ascorbate (2L PEG+Asc) or 1 L with added sodium sulfate (1L PEG+Asc). Before and after preparation, patients completed validated questionnaires on productivity, tolerability, and HRQoL. The primary outcome was the proportion of patients with adequate bowel preparation, aiming to demonstrate noninferiority of 1L PEG+Asc vs. 2

SUBMITTER: van Riswijk MLM 

PROVIDER: S-EPMC12828908 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature