Injectable multi-component hydrogels for the treatment of ascites caused by hepatocellular carcinoma via anti-tumor and reduction of ascites generation.

ABSTRACT: Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related death worldwide, and malignant ascites (MA) caused by HCC is almost incurable. However, the efficacy of chemotherapy is limited by poor tumor drug targeting and the presence of an immunosuppressive microenvironment. Therefore, it is urgent to find drugs for dual-therapy that have both anti-tumor effect and reduction of MA production. Inspired by self-assembly of two molecules, we enriched the effective parts of Genkwa Flos (GK), which was decocted with glycyrrhizic acid (GA) from licorice, one pot of green synthesis of an injectable multi-component hydrogel of TCM (GK-GA). The GK-GA hydrogel demonstrated excellent injectability and sustained retention properties in the peritoneal cavity following intraperiton

SUBMITTER: Yang Y 

PROVIDER: S-EPMC12828936 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature