Geographic distribution and genetic diversity of Brucella melitensis from Yunnan province, China.

ABSTRACT: Human brucellosis is a re-emerging disease in Yunnan, China, that poses serious threats to public health. However, the species/biovars, geographic distribution, and genetic diversity profile of circulating strains remain unclear. In this study, bacteriology procedures, AMOS-PCR, agglutination tests with anti-A and anti-M monospecific sera, and multiple-locus variable-number tandem-repeat analysis (MLVA) genotyping approaches were applied to investigate the genetic diversity profile of the strains. A total of 514 B. melitensis strains were isolated and identified from 2017 to 2023, of which 498 were in biovar (bv.) 3 and 16 were in bv. 1; the strains were distributed in 12 cities/prefectures and 67 counties. These data show that human B. melitensis infection has become a serious public heal

SUBMITTER: Yang Q 

PROVIDER: S-EPMC12828941 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature