What is a normal left ventricular ejection fraction in healthy adults? A meta-analysis of population-based echocardiographic studies.

ABSTRACT:

Background

Transthoracic echocardiography derived left ventricular ejection fraction (LVEF) is a cornerstone in heart failure risk prevention. However, the lower limits of normal LVEF remains imprecisely defined. We aimed to define normal LVEF ranges by sex, age group, and self-reported race/ethnicity using data from population-based echocardiographic studies.

Methods

We systematically searched MEDLINE for studies published between January 1, 2000, and January 3, 2025, that reported the mean and standard deviation of LVEF measured by 2D or 3D echocardiography in healthy, community-based adult populations.

Results

In 10 studies (n = 10,427; female sex, 48%), the pooled mean LVEF was 62.8% (95% confidence interval, 61.0%-64.7%), with estimated lower and upper normal lim

SUBMITTER: Morsing AE 

PROVIDER: S-EPMC12828944 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature