Exploring transmission dynamics in epidemiologically linked pulmonary tuberculosis cases and household contacts: a WGS-based investigation.

ABSTRACT:

Background

The genotyping of the M. tuberculosis complex has significantly enhanced the comprehension of transmission dynamics and is employed to substantiate transmission dynamics among epidemiologically interconnected cases. This investigation sought to examine genomic diversity, transmission dynamics, and mutations conferring drug resistance in epidemiologically linked pulmonary tuberculosis cases and their household contacts in central Ethiopia.

Methods

A total of 50 genomes were considered for WGS analysis using the TB- profiler pipeline for drug resistance and genotypic analysis (SNP distance cut-off 12).

Results

By analyzing the successful WGS data from 48 isolates, we identified that the majority were classified under lineages L4 (Euro-American, 33/48; 68.75%)

SUBMITTER: Seid G 

PROVIDER: S-EPMC12828947 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature