Organoids for disease modeling and treatment: state-of-the-art.

ABSTRACT: The emergence of organoids has received widespread attention for faithful recapitulation of physiological and pathological conditions, together with overcoming the major bottleneck of extrapolating laboratory findings from model systems to human organs. Organoid technologies are one of the most revolutionary breakthroughs in the fields of regenerative medicine and biomedical research. These three-dimensional (3D) micro-organ models are derived from stem cells and tissue derivatives, and can highly simulate the structure and function of parental organs, which thus open up unprecedented avenues for understanding organogenesis, disease modeling, drug screening and individualized therapeutics. In this review, we comprehensively elaborate on the core principles and key elements of organoid cons

SUBMITTER: Xu M 

PROVIDER: S-EPMC12828948 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature