Emodin for pulmonary fibrosis: a systematic review and meta-analysis of efficacy and molecular mechanisms.

ABSTRACT:

Objective

This systematic review and meta-analysis aimed to evaluate emodin's therapeutic efficacy in animal models of pulmonary fibrosis (PF) and summarize its anti-fibrotic mechanisms, providing a theoretical basis for the application of emodin in the clinical treatment of fibrosis.

Methods

A comprehensive literature search was conducted across 4 major international databases and 4 Chinese databases through July 2025. Study quality was assessed using the SYRCLE risk of bias tool. The mean difference (MD) or standardized mean difference (SMD) with 95% confidence intervals (CIs) was used to evaluate emodin's effects on fibrosis severity, histopathological damage, inflammation, oxidative stress, and epithelial-mesenchymal transition (EMT).

Results

Meta-analysis reveale

SUBMITTER: Zhou X 

PROVIDER: S-EPMC12828986 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature