Dataset Information
Partial inhibition of viral replication machinery enhances recombination in herpes simplex viruses.
Ontology highlight
ABSTRACT:
SUBMITTER: Ralph-Altman M
PROVIDER: S-EPMC12829068 | biostudies-literature | 2025 Dec
REPOSITORIES: biostudies-literature
Publications
Partial inhibition of viral replication machinery enhances recombination in herpes simplex viruses.
Biology direct 20251224 1
BACKGROUND: Herpes simplex viruses (HSV-1 and HSV-2) are widespread human pathogens, most commonly causing oral and genital lesions. These DNA viruses use recombination as a major driver of evolution. Intragenomic and intergenomic recombination events can be detected both in vivo and in vitro. As viral recombination is tightly linked to replication, deciphering mechanisms that specifically effect recombination remains a challenge. RESULTS: We employed a triple-fluorescent color recombination ass ...[more]