Urinary polyphenol signature of the Mediterranean diet is associated with lower cardiovascular disease risk: the PREDIMED trial.

ABSTRACT:

Background

The Mediterranean diet (MedDiet) is strongly associated with lower cardiovascular disease (CVD) risk and is particularly rich in polyphenols, bioactive compounds with potential cardioprotective effects. However, the specific phenolic compounds underlying these benefits remain unclear. The objective of this study was to develop a urinary multi-metabolite signature of phenolic compounds reflecting MedDiet adherence and to evaluate its prospective association with CVD risk.

Methods

In a case-cohort nested study within the PREDIMED trial, we measured 62 phenolic metabolites in spot urine by liquid chromatography-high-resolution mass spectrometry at baseline and after 1 year in 1180 individuals: 653 incident CVD cases (stroke, myocardial infarction, CVD death, or heart

SUBMITTER: Dominguez-Lopez I 

PROVIDER: S-EPMC12829081 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature