Bisphosphonates use is associated with increased coronary artery calcification in the general population: The Rotterdam study.

ABSTRACT:

Aims

Bisphosphonates may influence arterial calcification through mechanisms shared with bone formation. As treatment often extends over several years, assessing the arterial effects requires long-term follow-up. This population-based cohort estimated the long-term association of bisphosphonates with calcification across multiple key arterial sites.

Methods

We included 2399 Rotterdam Study participants with baseline CT-assessed calcification in the coronary arteries (CAC), aortic arch (AAC), and extra/intracranial carotid arteries (ECAC and ICAC). Among these, 815 participants underwent repeat CT after a mean of 13.6 years. Pharmacy-linked data provided cumulative information on bisphosphonate use from study entry to follow-up. Multivariable linear and mixed-effects regressi

SUBMITTER: Shahraki MN 

PROVIDER: S-EPMC12829121 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature