Longitudinal changes in the cystic fibrosis airway microbiota with time and treatment.

ABSTRACT:

Background

Whether there is any benefit in integrating culture-independent molecular analysis of the lower airway microbiota of people with cystic fibrosis into clinical care is unclear. This study determined the longitudinal trajectory of the microbiota and if there were microbiota characteristics that corresponded with response to treatment or predicted a future pulmonary exacerbation.

Methods

At least one sputum sample was collected from 149 participants enrolled in this prospective longitudinal multi-centre study and total bacterial density and microbiota community measurements were determined and compared with clinical parameters.

Results

In 114 participants with paired samples when clinically stable, ∼8 months apart, the microbiota remained conserved between tim

SUBMITTER: Einarsson GG 

PROVIDER: S-EPMC12829167 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature