Stability of blood eosinophils during acute exacerbations in patients with chronic obstructive pulmonary disease.

ABSTRACT:

Background

Blood eosinophils are recommended by GOLD as a biomarker for inhaled corticosteroid (ICS) therapy in COPD, yet their stability during acute exacerbations of COPD (AECOPD) remains uncertain.

Methods

We retrospectively analyzed 3,311 hospitalized AECOPD patients (2018-2023). Blood eosinophil distribution, longitudinal trends, and within-patient variability were assessed. Linear mixed-effects models estimated overall trajectories of ln(1 + EOS) over standardized hospital days (SHD). Variability was quantified by coefficient of variation (CV%), within-patient SD (wSD), and median absolute change between consecutive tests. Robustness of thresholds (100 and 300 cells/µL) was examined by crossing and reclassification rates, with simulations of 20-30% overall decline. Nea

SUBMITTER: Chen Q 

PROVIDER: S-EPMC12829177 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature