A positive feedback loop between KPNA2 and FOXM1 promotes the proliferation of lung adenocarcinoma.

ABSTRACT: Lung adenocarcinoma is a prevalent form of non-small cell lung cancer (NSCLC) that accounts for approximately 40% of all lung cancers. However, despite significant therapeutic advances in recent years, the overall survival of patients with lung adenocarcinoma remains poor. Consequently, it is necessary to identify further novel targets and drugs that can contribute to enhancing the prognosis of these patients. To this end, in this study, using siRNA silencing, we initially knocked down KPNA2 in lung adenocarcinoma cell lines, and performed CCK8 and 5-ethynyl-2'-deoxyuridine assays to examine the proliferation of lung adenocarcinoma. Chromatin immunoprecipitation was used to determine whether the transcription factor FOXM1 can bind to the promoter region of KPNA2, and we used AlphaFold3 to

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12829203 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature