Abnormal carnitine concentrations in critical illness associated with compromised outcome.

ABSTRACT:

Background

Carnitine deficiency affects mitochondrial and muscle function, but its relevance during critical illness remains unknown. Our aim was to investigate the relationship between plasma free carnitine concentrations and outcome in prolonged critical illness.

Methods

In this secondary analysis of the EPaNIC randomised controlled trial, abnormal plasma free carnitine concentrations, measured on ICU-day-6 (N = 1600), were defined by their association with a lower likelihood of an earlier alive ICU discharge (the primary endpoint) in a Cox proportional hazards model. Subsequently, they were binned based on their distribution and partial residuals in the Cox-model. Adjusted multivariable Cox-model and logistic regression analysed both association of abnormal carnitinemia w

SUBMITTER: Lauwers C 

PROVIDER: S-EPMC12829237 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature