Cost-effectiveness analysis of surgical and non-surgical weight loss interventions in end-stage knee osteoarthritis and obesity: a Markov State model.

ABSTRACT:

Background

The aim of the present study was to assess the cost-effectiveness of bariatric surgery, non-surgical weight loss and pharmacological non-surgical weight loss (BS-WL, NS-WL, PNS-WL) to avoid or delay total knee arthroplasty (TKA) in subjects with end-stage knee osteoarthritis and obesity.

Methods

The quality-adjusted life years (QALYs) and incremental cost-effectiveness ratio (ICER) were computed using a Markov State Model simulating outcomes and costs in 4000 potential subjects followed for 25 years. Model inputs were derived from the literature and internet sources. Deterministic and probabilistic sensitivity analyses were performed to assess the robustness of the model assumptions.

Results

BS-WL and PNS-WL increased QALYs from 7.70 (TKA-only group) to 8.9

SUBMITTER: Panunzi S 

PROVIDER: S-EPMC12829240 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature