Age-related differences in choroid plexus structural integrity are associated with changes in cognition.

ABSTRACT:

Background

The choroid plexus (CP) plays a critical role in maintaining central nervous system (CNS) homeostasis, producing cerebrospinal fluid, and regulating the entry of specific substances into the CNS from blood. CP dysfunction has been implicated in various neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis.

Methods

This study investigates the relationship between CP structural integrity and cognitive decline in normative aging, using structural and advanced magnetic resonance imaging techniques, including CP volume, diffusion tensor imaging indices (mean diffusivity, MD, and fractional anisotropy, FA) and relaxometry metrics (longitudinal, T₁, and transverse, T₂, relaxation times).

SUBMITTER: Gong Z 

PROVIDER: S-EPMC12829252 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature