Two-sample fecal immunochemical testing as a tool to avert colonoscopy in symptomatic patients: a prospective multicenter cohort study.

ABSTRACT: In most colonoscopies performed for bowel symptoms, no significant lesions are found. To decrease the number of unnecessary colonoscopies, we evaluated the performance of two-sample fecal immunochemical testing (FIT) in ruling out significant lesions.Symptomatic patients referred for colonoscopy were instructed to perform two FITs from separate bowel movements prior to colonoscopy. Colonoscopy and pathology data were collected. Two-sample FIT was considered positive when FIT1 and/or FIT2 results were positive. Sensitivity and negative predictive value (NPV) for advanced neoplasia, advanced serrated polyps, and colitis were determined at different cutoff values.949 patients (median age 61 years, 50.6% male) from 10 centers were included. The highest NPVs and sensitivities were reached with

SUBMITTER: Moen S 

PROVIDER: S-EPMC12829320 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature