Balancing stringency and feasibility: comparative value of disease-activity measures to predict pregnancy outcomes in systemic lupus erythematosus.

ABSTRACT:

Objective

To compare preconception disease-activity indices-systemic lupus erythematosus Disease Activity Score low disease activity (SLE-DAS LDA), lupus low disease activity state (LLDAS) and SLE-DAS remission-with Definitions of Remission in SLE (DORIS) remission in predicting adverse maternal and fetal outcomes among pregnant women with SLE.

Methods

This retrospective cohort study included 202 pregnancies in 196 women with SLE managed at Shenzhen People's Hospital between January 2017 and December 2024. Preconception disease activity was categorised using SLE-DAS, LLDAS and DORIS remission criteria. Main outcomes were maternal flares and fetal outcomes, including spontaneous abortion, therapeutic abortion, total fetal loss, preterm delivery and small for gestational age (

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12829344 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature