Test accuracy of glomerular filtration rate estimation with creatinine and cystatin C in adults with moderate chronic kidney disease: prospective cohort study.

ABSTRACT:

Objective

To study the performance of two contemporary sets of estimating equations for glomerular filtration rate, published by CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) and EKFC (European Kidney Function Consortium) that include one (creatinine or cystatin C only) and combined (creatinine and cystatin C) biomarkers, to assess their accuracy in a population with moderate chronic kidney disease.

Design

Prospective cohort study.

Setting

Primary, secondary, and tertiary care in six centres in England. Participants were recruited from April 2014 to January 2017.

Participants

1167 adults, aged ≥18 years, with moderate chronic kidney disease (estimated glomerular filtration rate 30-59 mL/min/1.73 m² sustained over at least three months b

SUBMITTER: Lamb EJ 

PROVIDER: S-EPMC12829397 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature