Bacteriophage vB_SalS_KY05 controls <i>Salmonella</i> in poultry without disrupting cecal microbiota composition.

ABSTRACT: Salmonellosis is a major food safety challenge in poultry production, requiring effective antibiotic alternatives. We isolated a polyvalent Tequintavirus, vB_SalS_KY05, from a Taiwanese poultry farm and evaluated its biological properties and in vivo efficacy against Salmonella enterica serovars Typhimurium and Enteritidis, and Escherichia coli. The objective of this study was to comprehensively characterize vB_SalS_KY05 and assess its potential as a biocontrol agent for poultry farming. Genome analysis confirmed a lytic lifestyle with no detectable virulence or antimicrobial resistance genes. The phage remained stable at pH 4-10, at 41 °C, and in water for 7 days. For improved biosafety, large-scale amplification was achieved by switching the propagation host t

SUBMITTER: Wu WY 

PROVIDER: S-EPMC12829423 | biostudies-literature | 2026 Dec

REPOSITORIES: biostudies-literature