Genetic risk for alcohol use disorder in relation to individual symptom criteria: Do polygenic indices provide unique information for understanding severity and heterogeneity?

ABSTRACT:

Background and aims

Previous studies have suggested that Alcohol Use Disorder (AUD) might result from separable genetic influences with symptoms reflecting differing degrees of genetic risk related to distinct risk mechanisms. The present study aimed to examine the genetic risk for individual AUD symptom criteria using a polygenic risk score (PRS) approach to assess the relative severity of each symptom and test for a multidimensional genetic structure of AUD.

Design

This retrospective study examined the correlation between genetic severity (i.e. PRS) and Item Response Theory (IRT) severity indices for each AUD symptom. Multiple Indicators Multiple Causes (MIMIC) models were employed to examine the effect of the PRS on individual AUD symptoms after accounting for overall AUD

SUBMITTER: Sarles YM 

PROVIDER: S-EPMC12829427 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature