Multi-responsive upconversion/organic porous silicon nanocomposite for controlled drug release <i>via</i> NIR irradiation and tumor microenvironment stimuli.

ABSTRACT: We report the synthesis of an organic/inorganic architecture, a rare-earth upconversion nanoparticle (UCNP)-based core with organic porous silicon shell nanocapsules, that enables visible and ultraviolet light emission under 980 nm near-infrared (NIR) irradiation for photodegradation. A mesoporous organosilica shell containing disulfide bonds was uniformly coated onto UCNP cores via a combined sol-gel and hard-template strategy. Glutathione (GSH) - triggered degradation of the nanocarriers was quantified using the molybdenum blue method. A photoresponsive azobenzene derivative, activatable by both UV and visible light, was synthesized and grafted onto the nanocarrier surface. Doxorubicin (DOX) was loaded into the nanocapsules, achieving a drug-loading capacity of 12.2 wt%. At neutra

SUBMITTER: Wang X 

PROVIDER: S-EPMC12829441 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature