Enhanced positronium lifetime imaging through two-component reconstruction in time-of-flight positron emission tomography.

ABSTRACT: Positronium lifetime imaging (PLI) is a newly demonstrated technique possible with time-of-flight (TOF) positron emission tomography (PET), capable of producing an image reflecting the lifetime of the positron, more precisely ortho-positronium (o-Ps), before annihilation, in addition to the traditional uptake image of the PET tracer. Due to the limited time resolution of TOF-PET systems and the added complexities in physics and statistics, lifetime image reconstruction presents a challenge. Recently, we described a maximum-likelihood approach for PLI by considering only o-Ps. In real-world scenarios, other populations of positrons that exhibit different lifetimes also exist. This paper introduces a novel two-component model aimed at enhancing the accuracy of o-Ps lifetime images. Through s

SUBMITTER: Chen Z 

PROVIDER: S-EPMC12829466 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature