Advancing the Development of Subcutaneous Glucose Biosensors: Cargo-Carrying Adhesive Biosensor Systems (CABs).

ABSTRACT: The development of an injectable, subcutaneous glucose biosensor may be advanced by utilizing optical glucose sensing assays. However, this requires a strategy to effectively house small-sized assay molecules. Herein, "CABs" or cargo-carrying adhesive biosensors were constructed via the electrostatic adhesion of a hollow rod membrane (whose cavity could store a liquid optical-assay) and hydrogel caps. For the CAB 'wall', the hollow rod leveraged a comb double network (DN) design previously shown to limit biofouling and reduce mesh size. To regulate the mesh size, poly(AMPS)-methacrylate (PAMPS_n-MA) comb macromers were incorporated into the 1st network. To improve electrostatic adhesivity, anionic 2-acrylamido-2-methylpropane sulfonic acid (AMPS) was incorporated into the second

SUBMITTER: Martinez CI 

PROVIDER: S-EPMC12829525 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature