Nanoprecipitation and Drug Delivery with PMTC: Toward Biomedical Application of Polyesters from Radical Ring-Opening Polymerization.

ABSTRACT: Polymerized cyclic ketene acetals (PCKAs) prepared by radical ring-opening polymerization (RROP) have shown tremendous potential in the biomedical field. In this work, the field is expanded to the formation of fully degradable nanoparticles (NPs) from the fast-degrading poly(2-methylene-1,3,6-trioxocane) (PMTC). The formulation of homopolymers is typically challenging due to their lack of amphiphilicity; however, implementing nanoprecipitation as a robust, fast, and cost-efficient method of self-assembly has yielded well-defined polymeric nanocarriers of 100-200 nm in diameter. The characterization of hydrophilicity and dye-encapsulation mediated via different polyester degrees of branching has enabled insights into utilizing this key characteristic of RROP. The degree of branching affecte

SUBMITTER: Axioti E 

PROVIDER: S-EPMC12829526 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature