Mitochondrial heterogeneity drives the evolution of fungicide resistance in <i>Phytophthora sojae</i>, with associated fitness trade-offs.

ABSTRACT: Mitochondrial complex III inhibitors, such as ametoctradin, are crucial for controlling oomycete diseases. However, the increasing severity of fungicide resistance necessitates urgent clarification of its evolutionary mechanisms to optimize disease management and delay resistance development. The DddA-derived cytosine base editors (DdCBEs)-mediated base editing in oomycetes confirmed that the PsCytb^S33L mutation is sufficient to confer ametoctradin resistance in Phytophthora sojae. We clarified that low-resistant and medium-resistant mutants serve as transitional populations during the resistance evolution process, with high-resistant mutants eventually becoming the dominant population. We revealed the dynamic changes in mitochondrial heterogeneity under fungicide

SUBMITTER: Yuan K 

PROVIDER: S-EPMC12829574 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature