TDRD3, a Tudor domain-containing protein, regulates <i>Klf2</i>-dependent T_reg differentiation and function to modulate immune tolerance.

ABSTRACT: Tudor domain-containing protein 3 (TDRD3) functions as a methylarginine reader that relays posttranslational arginine methylation signals to the transcriptional machinery, thereby regulating cellular functions through modulation of gene expression. Regulatory T cells (T_regs) are pivotal for establishing and maintaining immune tolerance. In this study, we demonstrate that mice with T_reg-specific deletion of Tdrd3 exhibit severely impaired iT_reg, but not thymic T_reg, differentiation. Moreover, iT_regs, but not thymic T_regs, derived from these mice fail to suppress colitis in adoptive transfer models, indicating compromised inhibitory capacity. Aged Tdrd3-deficient mice also show spontaneous autoinflammation. Mecha

SUBMITTER: Shi Y 

PROVIDER: S-EPMC12829583 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature