Matrix metalloproteinases-3 gene-promoter polymorphism as a risk factor in oral submucous fibrosis: A systematic review and meta-analysis.

ABSTRACT: Oral submucous fibrosis (OSF) is a progressive potentially malignant disorder. Matrix metalloproteinase-3 (MMP3) regulates extracellular matrix remodelling, and promoter polymorphisms may influence OSF susceptibility. This systematic review and meta-analysis evaluated the association between MMP3 expression, promoter polymorphism, and OSF risk. Electronic databases (PubMed, Cochrane, Google Scholar, ScienceDirect) were searched for studies published between 2000 and 2023, assessing MMP3 expression or promoter polymorphism in OSF. Four eligible studies were analysed using RevMan 5.4. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Heterogeneity was assessed using I² statistics, and publication bias using funnel plot asymmetry and Egger's te

SUBMITTER: Ghatage DD 

PROVIDER: S-EPMC12829639 | biostudies-literature | 2025 Oct-Dec

REPOSITORIES: biostudies-literature