Immunohistochemical expression of inflammasome-related proteins in head and neck squamous cell carcinoma tissues-A systematic review.

ABSTRACT:

Background

Inflammasomes are multiprotein complexes that play a crucial role in cancer pathogenesis, including in head and neck squamous cell carcinoma (HNSCC), by regulating inflammation, immune responses, and tumour progression. This systematic review aimed to synthesize current evidence on the immunohistochemical (IHC) expression of inflammasome-related proteins in human HNSCC tissues.

Methodology

A comprehensive search of PubMed, Scopus, Web of Science, LILACS, and Google Scholar was conducted up to 31 May 2025, following PRISMA 2020 guidelines and after prior registration in PROSPERO. Studies were included if they evaluated inflammasome-related proteins, such as NLRP3, ASC, caspase-1, and IL-1β, using IHC in human HNSCC tissues.

Results

Sixteen studies were eligi

SUBMITTER: Prasad H 

PROVIDER: S-EPMC12829657 | biostudies-literature | 2025 Oct-Dec

REPOSITORIES: biostudies-literature