Persistent foot-and-mouth disease virus infection of the bovine nasopharynx is associated with suppression of innate and cellular immunity.

ABSTRACT: Foot-and-mouth disease is a devastating disease of cattle that is caused by foot-and-mouth disease virus (FMDV). After acute infection, FMDV persists in the upper respiratory tract of about 50% of infected cattle. The persistent infection is characterized by very localized viral replication in the absence of clinical signs, but the underlying mechanisms are still not clear. In our study, we investigated tissue samples collected from 20 cattle which had been experimentally infected with FMDV O/FRA/1/2001. In 17 animals, the infection persisted for longer than 28 days. Epithelial tissue from the dorsal nasopharynx and the dorsal soft palate (DSP), the two main locations for persistent infection, was collected at necropsy. Five biological replicates from each animal and location were screened

SUBMITTER: Litz B 

PROVIDER: S-EPMC12829788 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature