Influence of follow-up, screening age, interval, and compliance on overdiagnosis of ductal carcinoma in situ (DCIS): A modelling study.

ABSTRACT: Overdiagnosis estimates of ductal carcinoma in situ (DCIS) vary from 20-91%, which complicates screening communication and optimization. The aim was to quantify the influence of follow-up time and screening setting on overdiagnosis of DCIS. The fully validated micro-simulation Markov model for DCIS (SimDCIS) was used to estimate DCIS overdiagnosis in different screening settings with varying follow-up. DCIS overdiagnosis was defined as the number of diagnosed DCIS (screen-, clinically detected, or progressed to invasive breast cancer) in screening that would not have been diagnosed without screening. Outcomes were presented as overdiagnosed proportion and rate. The base cohort was screened biennially from age 50-74 with 76% compliance and 25 years (y) follow-up and compared to the non-scre

SUBMITTER: Poelhekken K 

PROVIDER: S-EPMC12829814 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature