Intestinal decontamination with rifaximin attenuates LSEC dysfunction and liver fibrosis in mice.

ABSTRACT:

Background

The gut microbiome plays a pivotal role in the development and progression of liver disease. Liver sinusoidal endothelial cells (LSECs), as the first hepatic barrier exposed to blood from the portal circulation, may be influenced by gut-derived microbiota and their byproducts. This study aimed to investigate the interaction between gut microbiota and LSECs and to clarify how this interaction impacts the progression of liver cirrhosis.

Methods

Liver cirrhosis was induced by carbon tetrachloride (CCl4) injection and bile duct ligation (BDL). CCl4 and BDL mice were administered rifaximin. The primary LSECs were isolated from mice and treated with LPS. 16S rRNA sequencing was conducted to examine changes in the gut microbiota of cirrhotic mice following rifaximin trea

SUBMITTER: Su T 

PROVIDER: S-EPMC12829844 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature