Formononetin ameliorates SP-induced urticaria in mice via suppressing TAK1/MAK signaling pathway.

ABSTRACT:

Background

Chronic idiopathic urticaria (CIU) is a condition that significantly impacts patient well-being, requiring effective therapeutic strategies. Formononetin, a natural isoflavone with anti-inflammatory properties, has shown promise in allergic conditions. However, its specific effects and mechanism in CIU are not fully understood.

Methods

Comparative analyses were conducted between normal and formononetin-treated groups, along with mechanistic investigations into the TAK1/MAPK pathway both in vivo and in vitro. Cell morphology, cytokine secretion, histamine release, and TAK1/MAPK pathway alterations were assessed.

Results

Formononetin treatment led to a dose-dependent reduction in MC degranulation, histamine release, and secretion of inflammatory cytokines (TN

SUBMITTER: Wu Y 

PROVIDER: S-EPMC12829854 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature