Couple-close: Unified approach to semisaturated cyclic scaffolds.

ABSTRACT: Couple-close as a synthetic paradigm has the potential to change the way that synthetic organic chemists approach cyclic scaffold construction. One class of cyclic molecules that has been increasingly sought after is semisaturated cyclic scaffolds, whose specific blend of Csp²- and Csp³-hybridized components confers distinct properties to these species. However, existing methods to construct these scaffolds are limited, often relying on arene saturation or annulations that require lengthy de novo syntheses. Herein, we describe a unified and highly modular couple-close strategy for the synthesis of semisaturated scaffolds. This approach installs bifunctional linkers onto aromatic rings through a range of bond-forming reactions, and subsequent cyclization furnishes semi

SUBMITTER: Xie J 

PROVIDER: S-EPMC12829907 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature